Population genetics



We have taken advantage of comprehensive genotyping arrays and improved analytic tools to perform broad surveys of common and now rare genetic variation to identify novel factors contributing to cardiovascular risk.  For example, our genetic studies of blood pressure and hypertension have pointed to genes in the natriuretic peptide and nitric oxide/soluble guanylate cyclase pathways that converge on the production of cGMP. This has led to two grants focused on a) identifying causal variants that alter expression of the genes encoding atrial natriuretic peptide and soluble guanylate cyclase and b) establishing in human trials the impact of variants in these genes on response to dietary and pharmacologic interventions. [ICBP-GWAS Nature 2011]